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GMP PHARMACEUTICAL CLEAN ROOM HVAC SYSTEM KUSARUDZA UYE DESIGN

imba yakachena
gmp imba yakachena

Mukushongedza kweGMP mishonga yakachena kamuri, iyo HVAC system ndiyo inonyanya kukosha. Zvinogona kutaurwa kuti kana kudzora kwezvakatipoteredza kwekamuri rakachena kunogona kusangana nezvinodiwa zvakanyanya zvinoenderana neHVAC system. Heating ventilation uye air conditioning (HVAC) system inonziwo kucheneswa air conditioning system mumishonga GMP yakachena kamuri. Iyo HVAC sisitimu inonyanya kugadzirisa mhepo inopinda mukamuri uye inodzora tembiricha yemhepo, humidity, yakamiswa zvimedu, tupukanana, kudzvanywa musiyano uye zvimwe zvinongedzo zvenzvimbo yekugadzirwa kwemishonga kuona kuti maparamendi ezvakatipoteredza anosangana nezvinodiwa zvemhando yemishonga uye kudzivirira kuitika kwekusvibiswa kwemhepo uye kuyambuka. -kusvibiswa uku uchipa nzvimbo yakagadzikana yevashandisi. Pamusoro pezvo, mishonga yakachena kamuri HVAC masisitimu anogona zvakare kuderedza uye kudzivirira yakashata mhedzisiro yemishonga pavanhu panguva yekugadzira, uye kudzivirira nharaunda yakatenderedza.

Yakazara dhizaini yeair conditioning yekuchenesa system

Iyo yese unit yeair conditioning purification system uye zvikamu zvayo zvinofanirwa kugadzirwa zvinoenderana nezvinodiwa kwezvakatipoteredza. Iyo unit inonyanya kusanganisira zvikamu zvinoshanda sekudziya, kutonhora, humidification, dehumidification, uye kusefa. Zvimwe zvikamu zvinosanganisira mafeni ekupedza, kudzorera mafeni emhepo, kupisa simba rekugadzirisa zvirongwa, nezvimwewo. Panofanira kunge pasina zvinhu zvinowira mukati mehutano hweHVAC system, uye mapeji anofanira kunge ari maduku sezvinobvira kudzivirira kuunganidza guruva. Masisitimu eHVAC anofanirwa kuve nyore kuchenesa uye kushingirira kupfuhwira nekuuraya hutachiona.

1. HVAC system mhando

Air conditioning yekuchenesa masisitimu anogona kukamurwa kuita DC air conditioning masisitimu uye recirculation air conditioning masisitimu. Iyo DC air conditioning system inotumira iyo yakagadziriswa mhepo yekunze iyo inogona kusangana nezvinodiwa nzvimbo mukamuri, uyezve inoburitsa mhepo yese. Iyo sisitimu inoshandisa yese mhepo yakachena yekunze. Recirculation air conditioning system, kureva kuti, yakachena mukamuri mhepo inopa inosanganiswa nechikamu cheyakarapwa kunze kwemhepo yakachena uye chikamu chemhepo yekudzoka kubva munzvimbo yakachena yekamuri. Sezvo recirculation air conditioning system ine zvakanakira kuderera kwekutanga kudyara uye yakaderera mari yekushandisa, iyo recirculation air conditioning system inofanirwa kushandiswa zvine mwero sezvinobvira mukugadzira iyo air conditioning system. Mhepo mune dzimwe nzvimbo dzakakosha dzekugadzira haigone kushandiswazve, senge yakachena kamuri (nzvimbo) iyo guruva rinoburitswa panguva yekugadzira, uye kusvibiswa-kusvibiswa hakugone kudziviswa kana mhepo yemukati yakarapwa; organic solvents anoshandiswa mukugadzira, uye kuunganidza gasi kunogona kukonzera kuputika kana moto uye maitiro ane njodzi; nzvimbo dzekushanda kwepathogen; nzvimbo dzekugadzira mishonga yeradioactive; maitiro ekugadzira anoburitsa huwandu hukuru hwezvinhu zvinokuvadza, kunhuhwirira kana gasi rinoputika panguva yekugadzira.

Nzvimbo yekugadzira mishonga inogona kazhinji kukamurwa munzvimbo dzinoverengeka dzine hutsanana hwakasiyana. Nzvimbo dzakachena dzakasiyana dzinofanira kunge dzakashongedzerwa dzakazvimiririra mhepo inobata zvikamu. Imwe neimwe air conditioning system inopatsanurwa mumuviri kudzivirira kusvibiswa kwepakati pakati pezvigadzirwa. Yakazvimirira mhepo inobata zvikamu zvinogona zvakare kushandiswa munzvimbo dzakasiyana dzechigadzirwa kana kupatsanura nzvimbo dzakasiyana kupatsanura zvinhu zvinokuvadza kuburikidza nekuomarara kwemhepo kusefa uye kudzivirira kusvibiswa kwemuchinjiko kuburikidza nemhepo duct system, senge nzvimbo dzekugadzira, nzvimbo dzekubatsira dzekugadzira, nzvimbo dzekuchengetera, nzvimbo dzekutonga, nezvimwe. . inofanira kunge yakashongedzerwa neyakasiyana mhepo inobata unit. Kune nzvimbo dzekugadzira dzine akasiyana masisitimu ekushanda kana nguva dzekushandisa uye misiyano mikuru yetembiricha uye humidity yekudzora zvinodiwa, iyo mhepo inofefetera masisitimu inofanirwawo kugadzikwa zvakasiyana.

2. Mabasa uye zviyero

(1). Kupisa uye kutonhora

Nzvimbo yekugadzira inofanirwa kuchinjirwa kune zvinodiwa zvekugadzira. Kana pasina zvakakosha zvinodiwa pakugadzirwa kwemishonga, tembiricha yeKirasi C uye Kirasi D yakachena makamuri anogona kudzorwa pa18 ~ 26 ° C, uye tembiricha yemhando yeKirasi A uye Kirasi B yakachena makamuri inogona kudzorwa pa20 ~ 24. °C. Mukamuri yakachena air conditioning system, inopisa uye inotonhora makoiri ane kupisa kwekufambisa zvimbi, tubular magetsi ekudziya, nezvimwe zvinogona kushandiswa kupisa nekutonhodza mhepo, uye kubata mhepo kune tembiricha inodiwa nekamuri yakachena. Kana mhepo yakachena yakawanda, preheating yemhepo yakachena inofanira kufungwa kudzivirira macoil ezasi kubva kuchando. Kana kuti shandisa zvinopisa uye zvinotonhora zvinonyungudutsa, zvakadai semvura inopisa uye inotonhora, saturated steam, ethylene glycol, mafiriji akasiyana-siyana, nezvimwewo Pakusarudza zvinopisa uye zvinotonhora zvinonyungudutsa, zvinodiwa zvekupisa kwemhepo kana kutonhora kwemhepo, zvinodiwa zvehutsanana, unhu hwechigadzirwa, hupfumi, etc. Ita sarudzo inobva pamutengo uye mamwe mamiriro.

(2). Humidification uye dehumidification

Hunyoro hwemukamuri rakachena hunofanirwa kuenderana nezvinodiwa zvekugadzirwa kwemishonga, uye nharaunda yekugadzira mishonga uye kunyaradza kwevashandi kunofanirwa kuve nechokwadi. Kana pasina zvakakosha zvinodiwa pakugadzirwa kwemishonga, hunyoro hweKirasi C neKirasi D dzakachena nzvimbo dzinodzorwa pa45% kusvika 65%, uye hunyoro hwenzvimbo dzakachena dzeKirasi A neKirasi B inodzorwa pa45% kusvika 60%. .

Zvigadzirwa zvehupfu zvakasimwa kana kugadzirira kwakasimba kunoda yakaderera hukama humidity yekugadzira nharaunda. Dehumidifiers uye post-coolers inogona kutariswa kune dehumidification. Nekuda kwekudyara kwakanyanya uye mitengo yekushandisa, tembiricha yedova kazhinji inoda kudzikira pane 5°C. Nzvimbo yekugadzira ine hunyoro hwepamusoro inogona kuchengetedzwa nekushandisa chiutsi chefekitari, chiutsi chakachena chakagadzirirwa kubva mumvura yakacheneswa, kana kuburikidza nemhepo inopfungaira. Kana imba yakachena iine hunyoro hunodiwa, mhepo yekunze muzhizha inofanira kutonhodzwa neinotonhodza yozodziiswa nehita kuti igadzirise mwando. Kana indoor static magetsi ichida kudzorwa, humidification inofanirwa kutariswa munzvimbo dzinotonhora kana dzakaoma.

(3). Sefa

Huwandu hweguruva zvidimbu uye ma microorganisms mumhepo nyowani uye mhepo yekudzoka inogona kudzikiswa kusvika padiki kuburikidza nemafirita muHVAC system, ichibvumira nzvimbo yekugadzira kuti isangane neyakajairwa hutsanana zvinodiwa. Mune air-conditioning yekuchenesa masisitimu, kusefa kwemhepo kunowanzo kupatsanurwa kuita matanho matatu: pre-filtration, yepakati kusefa uye hepa filtration. Nhanho imwe neimwe inoshandisa mafirita emhando dzakasiyana. Iyo prefilter ndiyo yakaderera uye inoiswa pakutanga kweiyo air handling unit. Inogona kutora zvimedu zvakakura mumhepo (size size pamusoro pe 3 microns). Iyo yepakati filtration inowanikwa pasi pemvura ye-pre-filter uye inosungirirwa pakati pemhepo inobata chikwata apo mhepo yekudzoka inopinda. Inoshandiswa kutora zvidimbu zvidiki (pakukura kwepamusoro pe 0.3 microns). Iyo yekupedzisira filtration iri mu discharge chikamu chemhepo inobata unit, iyo inogona kuchengetedza pombi yakachena uye kuwedzera hupenyu hwesevhisi yeterminal sefa.

Kana kuchena kwemukamuri kwakakwira, hepa sefa inoiswa zasi kwerukova rwekupedzisira sefa yekusefa mudziyo. Iyo terminal sefa mudziyo unowanikwa kumagumo kweiyo air handle unit uye yakaiswa padenga kana kumadziro ekamuri. Inogona kuve nechokwadi chekupihwa kwemweya wakachena uye inoshandiswa kudzikisa kana kutumira zvimedu zvakaburitswa mukamuri yakachena, seKirasi B yakachena kamuri kana Kirasi A muKirasi B yakachena kamuri kumashure.

(4).Pressure control

Yakawanda yakachena kamuri inochengetedza kudzvanywa kwakanaka, nepo anteroom inotungamira kune ino imba yakachena inochengetedza zvakatevedzana kudzika uye kuderera kwakanaka kudzvanywa, kusvika kune zero yekutanga nhanho yenzvimbo dzisingadzoreki (zvivakwa zvakajairika). Kusiyana kwekumanikidzwa pakati penzvimbo dzakachena uye nzvimbo dzisina kuchena uye pakati penzvimbo dzakachena dzemazinga akasiyana-siyana haafaniri kuva pasi pe 10 Pa. Kana zvichidikanwa, zvakakodzera kudzvinyirira gradients inofanirawo kuchengetedzwa pakati penzvimbo dzakasiyana-siyana dzekushanda (makamuri ekushanda) ehutano hwakafanana. Iko kudzvanywa kwakanaka kunochengetwa mukamuri rakachena kunogona kuwanikwa nemhepo yekupa vhoriyamu yakakura kupfuura vhoriyamu yekuburitsa mweya. Kuchinja vhoriyamu yekugovera mweya kunogona kugadzirisa mutsauko wekumanikidza pakati pekamuri yega yega. Kugadzirwa kwezvinodhaka kwakakosha, senge penicillin mishonga, nzvimbo dzekushanda dzinoburitsa guruva rakawanda dzinofanira kuchengetedza dzvinyiriro isina kunaka.

pharmaceutical clean room
mhepo inobata chikwata

Nguva yekutumira: Zvita-19-2023
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